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Lancet子刊:间断性给药或可降低艰难梭菌感染的复发率

发布日期:2018-01-05来源:热心肠日报发布人:梦缘徽州

原标题:间断性给药是否是治疗艰难梭菌感染的答案?

① 抗生素治疗艰难梭菌感染的复发率较高,Benoit Guery在最新的一项临床试验中,使用了一种新的间断性给药方法;② 60岁以上的艰难梭菌感染患者随机分为2组,1组接受标准的万古霉素治疗,每日服药4次,每次125mg,持续10天;③ 另1组接受非达霉素延长间断性给药治疗,1-5天时,每日服药2次,每次200mg,接下来的20天,隔日服药,每次200mg;④ 在非达霉素延长间断性给药治疗的患者中,复发率显著低于标准的万古霉素治疗。

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The Lancet Infectious Diseases

[IF:19.864]

Is pulsed dosing the answer to treatment of Clostridium difficile infection?

DOI: 10.1016/S1473-3099(17)30750-8

Abstract:
Antibiotic treatment of Clostridium difficile infection has been plagued by high rates of recurrent diarrhoea attributed to C difficile and requiring retreatment, often repeatedly. In The Lancet Infectious Diseases, Benoit Guery and colleagues1 describe a novel dosing regimen for fidaxomicin in which the standard 200 mg, 20-dose, 10-day regimen is extended (the EXTEND study) by giving 200 mg twice daily for the first 5 days, followed by 200 mg every-other-day for an additional 20 days. The comparator regimen was standard-dose vancomycin (125 mg four times daily for 10 days), which is the same comparator dose that was used in two phase 3 licensing trials of standard-dose fidaxomicin (200 mg twice daily for 10 days).

First Authors:
Dale N Gerding

Correspondence:
Dale N Gerding

All Authors:
Dale N Gerding

2017-12-19Comment